Harvesting the untapped energy provided by ambient sources can provide power to sensors and micro devices, such as micro-antennas for wireless communications,without the need of changing batteries. Such a harvesting system can both enable monitoring of a structure and reduce downtime cost, especially in structural components being difficult or dangerous to access. Among energy harvesting material sources, piezoelectric materials are proved to be more efficient in terms of power density. The current project aims to the development of an autonomous system with respect to electric energy for monitoring and wireless transfer of sensory signals from wind turbine blades. The system includes piezoelectric elements for measuring strain and converting mechanical vibration energy into electric, and microelectronic circuitries for harvesting this energy and providing power to a micro-antenna in a sleep/wake-up mode. The latter will beam the acquired signals to a stationary router and from there to a cloud, which will provide blade-monitoring information. The project involves several design faces for the electromechanical and microelectronic subsystems, as well as, manufacturing of a final prototype to be installed on a wind turbine blade. The project’s partner scheme includes two top research labs for mechatronics and piezoelectrics and two industrial partners highly specialized in microelectronics and in the management of wind energy parks. The outcome is expected to provide extremely high added value to all partners, since the proposed system is novel and can be extended easily to a vast variety of structural applications.